Massachusetts is a thriving hub for innovation, home to a dynamic ecosystem of startups across industries such as technology, healthcare, and life sciences. Fueling this innovation are a number of active venture capital (VC) firms headquartered in the region. These firms play a pivotal role in shaping the future of the entrepreneurial landscape by providing essential funding, mentorship, and strategic guidance to emerging companies. From early-stage investments to large-scale exits, Massachusetts-based VC firms are instrumental in propelling startups to success. Below, we highlight some of the most prominent and active VC firms based in Massachusetts, their leadership, and their notable portfolio companies.

.406 Ventures

• 🏦 HQ: Boston, Massachusetts,(USA)

• 👨‍💻👩‍💻 Leadership: Liam Donohue

• 🔢 Number of Investments: 150-200

• 💰️ Number of Exits: 10-50

• 👜 Notable Portfolio companies: Abacus Insights, AbleTo, AristaMD

Atlas Venture

• 🏦 HQ: Cambridge, Massachusetts,(USA)

• 👨‍💻👩‍💻 Leadership: Bruce Booth, David Grayzel, Jason Rhodes, Jean-François Formela, Kevin Bitterman, Michael Gladstone, Peter Barrett

• 🔢 Number of Investments: 500-1000

• 💰️ Number of Exits: 100-200

• 👜 Notable Portfolio companies: aavantgarde, aerovate, Akero

Battery Ventures

• 🏦 HQ: Boston, Massachusetts,(USA)

• 👨‍💻👩‍💻 Leadership: Jesse Feldman, Michael Brown, Morad Elhafed, Neeraj Agrawal, Russell Fleischer, Zack Smotherman, Jordan Welu

• 🔢 Number of Investments: 500-1000

• 💰️ Number of Exits: 100-300

• 👜 Notable Portfolio companies: Galileo, Databricks, Workato, Gong, Neuron7

F-Prime Capital

• 🏦 HQ: Cambridge, Massachusetts,(USA)

• 👨‍💻👩‍💻 Leadership: Stephen Knight

• 🔢 Number of Investments: 400-500

• 💰️ Number of Exits: 90-100

• 👜 Notable Portfolio companies: BenchSci, EQUIP, FoldRx

Flybridge

• 🏦 HQ: Boston, Massachusetts,(USA)

• 👨‍💻👩‍💻 Leadership: Chip Hazard, Jeff Bussgang

• 🔢 Number of Investments: 500-1000

• 💰️ Number of Exits: 50-100

• 👜 Notable Portfolio companies: Arcee, proscia, Oasis

Founder Collective

• 🏦 HQ: Cambridge, Massachusetts,(USA)

• 👨‍💻👩‍💻 Leadership: David Frankel, Eric Paley, Micah Rosenbloom

• 🔢 Number of Investments: 500-600

• 💰️ Number of Exits: 100-150

• 👜 Notable Portfolio companies: Uber, Airops, Airtable, Alyce

General Catalyst

• 🏦 Offices: Cambridge, Massachusetts,(USA)

• 👨‍💻👩‍💻 Leadership: Hemant Taneja

• 🔢 Number of Investments: 500-1000

• 💰️ Number of Exits: 200-300

• 👜 Notable Portfolio companies: Airbnb, Canva, Snap, IBM, Discord

Mass Ventures

• 🏦 HQ: Waltham, Massachusetts,(USA)

• 👨‍💻👩‍💻 Leadership: Charlie Hipwood, Vinit Nijhawan

• 🔢 Number of Investments: 400-500

• 💰️ Number of Exits: 70-100

• 👜 Notable Portfolio companies: AeroShield, Eden, Florrent, inkbit

MPM BioImpact

• 🏦 HQ: Boston, Massachusetts,(USA)

• 👨‍💻👩‍💻 Leadership: Christiana Bardon, Ansbert Gadicke

• 🔢 Number of Investments: 100-150

• 💰️ Number of Exits: 50-100

• 👜 Notable Portfolio companies: Aktis Oncology, Orna, Arialys

Polaris Partners

• 🏦 HQ: Boston, Massachusetts,(USA)

• 👨‍💻👩‍💻 Leadership: Brian Chee, Amy Schulman

• 🔢 Number of Investments: 500-1000

• 💰️ Number of Exits: 100-300

• 👜 Notable Portfolio companies: Ajax Health, Adimab, 65LAB, AIR

RA Capital

• 🏦 HQ: Boston, Massachusetts,(USA)

• 👨‍💻👩‍💻 Leadership: Peter Kolchinsky, Rajeev Shah

• 🔢 Number of Investments: 400-500

• 💰️ Number of Exits: 100-200

• 👜 Notable Portfolio companies: Superluminal Medicines, Navigator Medicines, Enara Bio

SV Health Investors

• 🏦 HQ: Boston, Massachusetts,(USA)

• 👨‍💻👩‍💻 Leadership: Michael Balmuth, Tom Flynn, Paul LaViolette, Greg Madden, Nikola Trbovic

• 🔢 Number of Investments: 100-200

• 💰️ Number of Exits: 50-100

• 👜 Notable Portfolio companies: Adimab, AdaptHealth, Alchemab

Venture capital firms in Massachusetts continue to be a driving force behind innovation across industries, fostering groundbreaking companies and transformative technologies. With a strong presence in sectors like healthcare, biotechnology, software, and fintech, these firms are helping shape the next generation of industry leaders. From their impressive investment portfolios to their impactful exits, the firms listed above are key players in sustaining Massachusetts’ reputation as one of the premier hubs for entrepreneurship and venture capital in the U.S. As they continue to invest in cutting-edge solutions, they are not only supporting local startups but also contributing to global advancements across multiple sectors.